Intraosseous Versus Intravenous Infusion of Hydroxocobalamin for the Treatment Of Acute Severe Cyanide Toxicity in a Swine Model
Abstract
Easily administrated cyanide antidotes are needed for first responders, military troops, and emergency department staff after cyanide exposure in mass casualty incidents or due to smoke inhalation during fires involving many victims. Hydroxocobalamin has proven to be an effective antidote, but cannot be given intramuscularly because the volume of diluent needed is too large. Thus, intraosseous (IO) infusion may be an alternative, as it is simple and has been recommended for the administration of other resuscitation drugs. The primary objective of this study was to compare the efficacy of IO delivery of hydroxocobalamin to intravenous (IV) injection for the management of acute cyanide toxicity in a well‐described porcine model.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 01, 2014
- Source ID
- 10.1111/acem.12518
Entities
People
- David A. Tanen
- Rebecca L. Pitotti
- Susan Boudreau
- Vikhyat S Bebarta
Organizations
- San Antonio Military Medical Center
- United States Air Force
- University of California, Los Angeles