Dual‐Trait Selection for Ethanol Consumption and Withdrawal: Genetic and Transcriptional Network Effects
Abstract
Data from C57BL/6J (B6) × DBA/2J (D2) F2 intercrosses (B6xD2 F2), standard and recombinant inbred strains, and heterogeneous stock mice indicate that a reciprocal (or inverse) genetic relationship exists between alcohol consumption and withdrawal severity. Furthermore, some genetic studies have detected reciprocal quantitative trait loci (QTLs) for these traits. We used a novel mouse model developed by simultaneous selection for both high alcohol consumption/low withdrawal and low alcohol consumption/high withdrawal and analyzed the gene expression and genome‐wide genotypic differences.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 01, 2014
- Source ID
- 10.1111/acer.12574
Entities
People
- Alexandre Colville
- Christina A. Harrington
- Denesa Oberbeck
- John C. Crabbe
- John K. Belknap
- Kari J. Buck
- Nicole A. R. Walter
- Ovidiu D. Iancu
- Pamela Metten
- Robert J. Hitzemann
- Shannon Mcweeney
- Stephanie E. Spence
- Tamara J. Phillips
Organizations
- National Center for Research Resources
- National Institute on Alcohol Abuse and Alcoholism
- United States Department of Defense
- United States Department of Veterans Affairs