Metabolomics Analysis Revealed Distinct Cyclic Changes of Metabolites Altered by Chronic Ethanol‐Plus‐Binge and Shp Deficiency

Abstract

Chronic ethanol (EtOH) consumption causes alcoholic liver disease (ALD), and disruption of the circadian system facilitates the development of ALD. Small heterodimer partner (SHP) is a nuclear receptor and critical regulator of hepatic lipid metabolism. This study aimed at depicting circadian metabolomes altered by chronic EtOH‐plus‐binge and Shp deficiency using high‐throughput metabolomics.

Document Details

Document Type
Pub Defense Publication
Publication Date
Oct 28, 2016
Source ID
10.1111/acer.13257

Entities

People

  • Li Wang
  • Melanie Tran
  • Suthat Liangpunsakul
  • Zhihong Yang

Organizations

  • Indiana University
  • National Institutes of Health
  • National Natural Science Foundation of China
  • United States Department of Defense
  • University of Connecticut
  • Wenzhou Medical University
  • Yale University

Tags

Fields of Study

  • Medicine

Readers

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  • Toxicology/Environmental Toxicology