Effects of Alcohol and Estrogen Receptor Blockade Using ICI 182,780 on Bone in Ovariectomized Rats
Abstract
Estrogen signaling is essential for the sexual dimorphism of the skeleton, is required for normal bone remodeling balance in adults, and may influence the skeletal response to alcohol. High levels of alcohol consumption lower bone mass in ovary‐intact but not ovariectomized (ovx) rats. However, the extremely rapid rate of bone loss immediately following ovx may obscure the effects of alcohol. We therefore determined (i) whether heavy alcohol consumption (35% caloric intake) influences bone in sexually mature ovx rats with established cancellous osteopenia and (ii) whether ICI 182,780 (ICI), a potent estrogen receptor signaling antagonist, alters the skeletal response to alcohol.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 17, 2019
- Source ID
- 10.1111/acer.14185
Entities
People
- Adam J. Branscum
- Amida F. Kuah
- Carmen P. Wong
- Dawn A. Olson
- Gianni F. Maddalozzo
- Kathy Howe
- Kenneth A. Philbrick
- Lindsay Wagner
- Russell T Turner
- Urszula T Iwaniec
Organizations
- National Institute on Alcohol Abuse and Alcoholism
- Oregon State University
- United States Department of Defense