Regional blood acidification inhibits coagulation during extracorporeal carbon dioxide removal (ECCO2R)
Abstract
Consumption of platelets and coagulation factors during extracorporeal carbon dioxide removal (ECCO2R) increases bleeding complications and associated mortality. Regional infusion of lactic acid enhances ECCO2R by shifting the chemical equilibrium from bicarbonate to carbon dioxide. Our goal was to test if regional blood acidification during ECCO2R inhibits platelet function and coagulation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 25, 2022
- Source ID
- 10.1111/aor.14233
Entities
People
- Andrew D Meyer
- Andrew P Cap
- Andriy I. Batchinsky
- Jeremy Cannon
- Leopoldo C. Cancio
- Nicolas J. Prat
- Vittorio Scaravilli
Organizations
- United States Army Institute of Surgical Research
- United States Department of Defense
- University of Milan
- University of Pennsylvania