Pre‐transplant short telomeres are associated with high mortality risk after unrelated donor haematopoietic cell transplant for severe aplastic anaemia
Abstract
Telomeres are essential for chromosomal stability and markers of biological age. We evaluated the effect of pre‐transplant short (N = 80, 71·43%). RTL P = 0·006) compared with RTL ≥50th percentile; no survival differences were noted in longer RTL categories (P > 0·10). Time‐dependent effects for post‐HCT mortality were only observed in relation to very short RTL; HR comparing RTL versus ≥5th percentile = 1·38, P = 0·15 for the first 12 months after HCT, and HR = 3·91, P P‐heterogeneity = 0·008; the corresponding HRs for RTL versus ≥1st percentile = 1·29, P = 0·41, and HR = 5·18, P P‐heterogeneity = 0·005. The study suggests a potential role for telomere length in risk stratification of SAA patients in regard to their HCT survival.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 19, 2019
- Source ID
- 10.1111/bjh.16153
Entities
People
- Belynda Hicks
- Casey Dagnall
- Hormuzd A. Katki
- Kristine Jones
- Lisa J McReynolds
- Neal D. Freedman
- Shahinaz Gadalla
- Sharon A. Savage
- Stephanie J. Lee
- Stephen R. Spellman
- Tao Wang
- Youjin Wang
Organizations
- Center for International Blood and Marrow Transplant Research
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Fred Hutchinson Cancer Center
- Medical College of Wisconsin
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases
- Office of Naval Research