Incidence, Risk Factors for and Outcomes of Transplant‐Associated Thrombotic Microangiopathy
Abstract
Transplant‐associated thrombotic microangiopathy (TA‐TMA) is a complication of allogeneic transplantation (allo‐HCT). The incidence and risk factors associated with TA‐TMA are not well known. A retrospective analysis from the Center for International Blood and Marrow Transplant Research (CIBMTR) was conducted including patients receiving allo‐HCT between 2008 and 2016, with the primary objective of evaluating the incidence of TA‐TMA. Secondary objectives included identification of risk factors associated with TA‐TMA, and the impact of TA‐TMA on overall survival and the need for renal replacement therapy (RRT). Among 23,665 allo‐HCT recipients, the 3‐year cumulative incidence of TA‐TMA was 3%. Variables independently‐associated with increased incidence of TA‐TMA included female sex, prior autologous transplant, primary disease (acute lymphoblastic leukaemia and severe aplastic anaemia), donor type (mismatched or unrelated donor), conditioning intensity (myeloablative), GVHD prophylaxis (sirolimus + calcineurin inhibitor), pre‐transplant kidney dysfunction and acute GVHD (time‐varying effect). TA‐TMA was associated with higher mortality (HR = 3·1, 95% Confidence Interval [CI] = 2·8–16·3) and RRT requirement (HR = 7·1, 95% CI = 5·7–311·6). This study provides epidemiologic data on TA‐TMA and its impact on transplant outcomes. Increased awareness of the risk factors will enable providers to be vigilant of this uncommon but serious transplant complication. The results will also provide benchmarking for future study designs and comparisons.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 02, 2020
- Source ID
- 10.1111/bjh.16457
Entities
People
- Alison Loren
- Ang Li
- Baldeep Wirk
- Brent Logan
- Caitrin Fretham
- César O. Freytes
- Edward Copelan
- Hillard M Lazarus
- Jean A. Yared
- Lynette Chee
- Mahmoud Aljurf
- Marcelo C Pasquini
- Mark R Litzow
- Narendranath Epperla
- Peiman Hematti
- Richard F. Olsson
- Saurabh Chhabra
- Taiga Nishihori
- Tim Prestidge
- Wael Saber
Organizations
- Case Western Reserve University
- H. Lee Moffitt Cancer Center & Research Institute
- Karolinska Institutet
- Levine Cancer Institute
- Mayo Clinic
- Medical College of Wisconsin
- National Cancer Institute
- National Institutes of Health
- National Marrow Donor Program
- Office of Naval Research
- Ohio State University
- Royal Melbourne Hospital
- Seattle Cancer Care Alliance
- University of Pennsylvania
- University of Washington
- University of Wisconsin–Madison
- Uppsala University