Does recipient body mass index inform donor selection for allogeneic haematopoietic cell transplantation?
Abstract
It is not known whether obesity has a differential effect on allogeneic haematopoietic cell transplantation outcomes with alternative donor types. We report the results of a retrospective registry study examining the effect of obesity [body mass index (BMI) > 30] on outcomes with alternative donors (haploidentical related donor with two or more mismatches and receiving post‐transplant cyclophosphamide [haplo] and cord blood (CBU)] versus matched unrelated donor (MUD). Adult patients receiving haematopoietic cell transplantation for haematologic malignancy (2013–2017) (N = 16 182) using MUD (n = 11 801), haplo (n = 2894) and CBU (n = 1487) were included. The primary outcome was non‐relapse mortality (NRM). The analysis demonstrated a significant, non‐linear interaction between pretransplant BMI and the three donor groups for NRM: NRM risk was significantly higher with CBU compared to haplo at BMI 25–30 [hazard ratio (HR) 1.66–1.71, p p < 0.05). The results demonstrated that NRM and survival outcomes are worse in overweight and obese transplant recipients (BMI ≥ 25) with one alternative donor type over MUD, although obesity does not appear to confer a uniform differential mortality risk with one donor type over the other. BMI may serve as a criterion for selecting a donor among the three (MUD, haplo and CBU) options, if matched sibling donor is not available.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 14, 2022
- Source ID
- 10.1111/bjh.18108
Entities
People
- Akshay Sharma
- Amer M. Beitinjaneh
- Bipin N Savani
- Edward A. Stadtmauer
- Gayathri Ravi
- Hillard M Lazarus
- Kwang Woo Ahn
- Leland Metheny Iii
- Marcelo C Pasquini
- Marcos de Lima
- Mariam Allbee‐johnson
- Mohamed L Sorror
- Mouhamed Yazan Abou‐ismail
- Najla El Jurdi
- Neel S Bhatt
- Peiman Hematti
- Raphael Fraser
- Saurabh Chhabra
- Sherif M Badawy
- Taiga Nishihori
Organizations
- Case Western Reserve University
- Fred Hutchinson Cancer Center
- H. Lee Moffitt Cancer Center & Research Institute
- Health Resources and Services Administration
- Medical College of Wisconsin
- Northwestern University
- Office of Naval Research
- Ohio State University
- St. Jude Children's Research Hospital
- University of Alabama at Birmingham
- University of Miami
- University of Minnesota
- University of Pennsylvania
- University of Utah
- University of Washington
- University of Wisconsin–Madison
- Vanderbilt University