The Neuropathology of Chronic Traumatic Encephalopathy
Abstract
Repetitive brain trauma is associated with a progressive neurological deterioration, now termed as chronic traumatic encephalopathy (CTE). Most instances of CTE occur in association with the play of sports, but CTE has also been reported in association with blast injuries and other neurotrauma. Symptoms of CTE include behavioral and mood changes, memory loss, cognitive impairment and dementia. Like many other neurodegenerative diseases, CTE is diagnosed with certainty only by neuropathological examination of brain tissue. CTE is a tauopathy characterized by the deposition of hyperphosphorylated tau (p‐tau) protein as neurofibrillary tangles, astrocytic tangles and neurites in striking clusters around small blood vessels of the cortex, typically at the sulcal depths. Severely affected cases show p‐tau pathology throughout the brain. Abnormalities in phosphorylated 43 kDa TAR DNA‐binding protein are found in most cases of CTE; beta‐amyloid is identified in 43%, associated with age. Given the importance of sports participation and physical exercise to physical and psychological health as well as disease resilience, it is critical to identify the genetic risk factors for CTE as well as to understand how other variables, such as stress, age at exposure, gender, substance abuse and other exposures, contribute to the development of CTE.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 23, 2015
- Source ID
- 10.1111/bpa.12248
Entities
People
- Ann C. Mckee
- Patrick T. Kiernan
- Thor D Stein
- Victor E. Alvarez
Organizations
- Boston University
- National Institute of Neurological Disorders and Stroke
- National Operating Committee on Standards for Athletic Equipment
- United States Department of Defense
- United States Department of Veterans Affairs