Supraspinal actions of nociceptin/orphanin FQ, morphine and substance P in regulating pain and itch in non‐human primates
Abstract
Nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor agonists display a promising analgesic profile in preclinical studies. However, supraspinal N/OFQ produced hyperalgesia in rodents and such effects have not been addressed in primates. Thus, the aim of this study was to investigate the effects of centrally administered ligands on regulating pain and itch in non‐human primates. In particular, nociceptive thresholds affected by intracisternal N/OFQ were compared with those of morphine and substance P, known to provide analgesia and mediate hyperalgesia, respectively, in humans.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 24, 2015
- Source ID
- 10.1111/bph.13124
Entities
People
- D D Sukhtankar
- H. Ding
- K Hayashida
- M. Kimura
- Mei-Chuan Ko
- T Suto
- V Mendenhall
Organizations
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Institute on Drug Abuse
- United States Department of Defense
- Wake Forest University