CGRP receptor activity in mice with global expression of human receptor activity modifying protein 1
Abstract
CGRP is a potent vasodilator and nociceptive neuropeptide linked to migraine. CGRP receptors are heterodimers of receptor activity modifying protein 1 (RAMP1) and either calcitonin receptor‐like receptor (CLR; forms canonical CGRP receptor) or calcitonin receptor (CT receptor; forms AMY1 receptor). The goal of this study was to test whether transgenic mice globally expressing human RAMP1 have increased CGRP receptor activity and whether the receptors are sensitive to human selective antagonist telcagepant.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 22, 2017
- Source ID
- 10.1111/bph.13783
Entities
People
- Adisa Kuburas
- Andrew F Russo
- Anne‐sophie Wattiez
- Baolin Li
- Beverly A. Heinz
- Bianca N. Mason
- Christopher S Walker
- Jianliang Yu
- Keegan J Bohn
- Kirk W. Johnson
- Peiyi Yang
- Xiaofang Huang
Organizations
- Auckland Medical Research Foundation
- Eli Lilly and Company
- National Institute of Neurological Disorders and Stroke
- United States Department of Defense
- United States Department of Veterans Affairs
- University of Auckland
- University of Iowa
- Veterans Health Administration