G protein‐biased kratom‐alkaloids and synthetic carfentanil‐amide opioids as potential treatments for alcohol use disorder
Abstract
Mitragyna speciosa, more commonly known as kratom, is a plant that contains opioidergic alkaloids but is unregulated in most countries. Kratom is used in the self‐medication of chronic pain and to reduce illicit and prescription opioid dependence. Kratom may be less dangerous than typical opioids because of the stronger preference of kratom alkaloids to induce receptor interaction with G proteins over β‐arrestin proteins. We hypothesized that kratom (alkaloids) can also reduce alcohol intake.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 24, 2020
- Source ID
- 10.1111/bph.14913
Entities
People
- Anna M. Gutridge
- Gavril W. Pasternak
- Kendall L. Mores
- Mee Jung Ko
- Meridith T. Robins
- Rajendra Uprety
- Richard M van Rijn
- Robert J. Cassell
- Susruta Majumdar
Organizations
- Brain & Behavior Research Foundation
- Center for Strategic Scientific Initiatives, National Cancer Institute
- Mayday Fund
- Memorial Sloan Kettering Cancer Center
- National Institute on Alcohol Abuse and Alcoholism
- Office of the Secretary of Defense
- Purdue University
- Washington University in St. Louis