Possible mechanisms of cancer prevention by nicotinamide
Abstract
Nicotinamide (NAM) is a precursor of vitamin B3 commonly sold over the counter as a nutritional supplement with anti‐aging properties. Accumulating preclinical evidence indicates that NAM also mediates oncopreventive effects against a variety of neoplasms. Supporting the translational relevance of dietary NAM supplementation, results from a Phase 3 randomized clinical trial have demonstrated that oral NAM was safe and efficiently reduced the incidence of new non‐melanoma skin cancers and actinic keratosis amongst high‐risk individuals. However, the molecular and cellular mechanisms that underlie this ability of NAM to delay carcinogenesis remain to be clarified, as discussed in this short review.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 03, 2020
- Source ID
- 10.1111/bph.15096
Entities
People
- Aitziber Buqué
- Guido Kroemer
- Lorenzo Galluzzi
- Norma Bloy
Organizations
- Karolinska University Hospital
- United States Department of Defense
- University of Paris
- Weill Cornell Medicine
- Yale School of Medicine