Structural determinants of TRPV4 inhibition and identification of new antagonists with antiviral activity
Abstract
The transient receptor potential vanilloid 4 (TRPV4) cation channel participates in multiple physiological processes and is also at the core of different diseases, making this channel an interesting pharmacological target with therapeutic potential. However, little is known about the structural elements governing its inhibition.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 15, 2020
- Source ID
- 10.1111/bph.15267
Entities
People
- Fanny Rubio‐moscardo
- Fernando González‐nilo
- Gemma Pérez‐vilaró
- Jonathan Canan
- Juana Díez
- Miguel A. Valverde
- Pablo Doñate‐macian
- Yorley Duarte
Organizations
- Andrés Bello University
- Ministry of Science of Spain
- Pompeu Fabra University
- United States Army Institute of Surgical Research
- University of Valparaíso