Ovarian cancer risk, ALDH2 polymorphism and alcohol drinking: Asian data from the Ovarian Cancer Association Consortium
Abstract
The aldehyde dehydrogenase 2 (ALDH2) polymorphism rs671 (Glu504Lys) causes ALDH2 inactivation and adverse acetaldehyde exposure among Asians, but little is known of the association between alcohol consumption and rs671 and ovarian cancer (OvCa) in Asians. We conducted a pooled analysis of Asian ancestry participants in the Ovarian Cancer Association Consortium. We included seven case‐control studies and one cohort study comprising 460 invasive OvCa cases, 37 borderline mucinous OvCa and 1274 controls of Asian descent with information on recent alcohol consumption. Pooled odds ratios (OR) with 95% confidence intervals (CI) for OvCa risk associated with alcohol consumption, rs671 and their interaction were estimated using logistic regression models adjusted for potential confounders. No significant association was observed for daily alcohol intake with invasive OvCa (OR comparing any consumption to none = 0.83; 95% CI = 0.58‐1.18) or with individual histotypes. A significant decreased risk was seen for carriers of one or both Lys alleles of rs671 for invasive mucinous OvCa (OR = 0.44; 95% CI = 0.20‐0.97) and for invasive and borderline mucinous tumors combined (OR = 0.48; 95% CI = 0.26‐0.89). No significant interaction was observed between alcohol consumption and rs671 genotypes. In conclusion, self‐reported alcohol consumption at the quantities estimated was not associated with OvCa risk among Asians. Because the rs671 Lys allele causes ALDH2 inactivation leading to increased acetaldehyde exposure, the observed inverse genetic association with mucinous ovarian cancer is inferred to mean that alcohol intake may be a risk factor for this histotype. This association will require replication in a larger sample.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 21, 2018
- Source ID
- 10.1111/cas.13470
Entities
People
- Andrew Berchuck
- Anna H. Wu
- Celeste Leigh Pearce
- Daniel W. Cramer
- David Van Den Berg
- Georgia Chenevix‐trench
- Hui Cai
- Jennifer A Doherty
- Joellen M. Schildkraut
- Jue‐sheng Ong
- Kathryn L. Terry
- Keitaro Matsuo
- Kristine G. Wicklund
- Linda E Kelemen
- Lynne R. Wilkens
- Malcom C Pike
- Marc T. Goodman
- Mary Anne Rossing
- Michael E. Carney
- Mika Mizuno
- On Behalf Of The Australian Ovarian Cancer Study Group
- On Behalf Of The Ovarian Cancer Association Consortium
- Pamela J. Thompson
- Penelope M. Webb
- Tomotaka Ugai
- Xiao‐ou Shu
- Yong‐bing Xiang
- Yu‐tang Gao
Organizations
- Aichi Cancer Center Hospital
- Brigham and Women's Hospital
- Canadian Institutes of Health Research
- Cancer Research UK
- Cedars-Sinai Medical Center
- Duke University
- Fred Hutchinson Cancer Center
- Japan Society for the Promotion of Science
- Jichi Medical University
- Medical University of South Carolina
- Memorial Sloan Kettering Cancer Center
- Ministry of Health
- Nagoya University
- National Institutes of Health
- Ovarian Cancer Research Alliance
- QIMR Berghofer Medical Research Institute
- Shanghai Jiao Tong University
- The Breast Cancer Research Foundation
- United States Army Medical Research and Development Command
- United States Department of Defense
- University of Hawaiʻi System
- University of Michigan
- University of Southern California
- University of Utah
- University of Virginia
- University of Washington
- Vanderbilt University