Rush desensitization with a single antigen induces subclinical activation of mast cells and protects against bystander challenge in dually sensitized mice
Abstract
Rush desensitization can provide short‐term tolerance to individuals who are allergic to certain medications in instances where other therapeutic interventions are limited. While rush desensitization (DS) is typically successful in preventing adverse type I hypersensitivity reactions, the mechanism of allergic protection remains unknown. Given the rise in prevalence of individuals displaying multiple allergies, understanding the impact of rush DS on “bystander” allergens, or additional allergens to which an individual is sensitized, could help inform clinical recommendations.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 16, 2019
- Source ID
- 10.1111/cea.13323
Entities
People
- Alyssa R Lindrose
- David Cook
- Edward Mitre
- Holly E. Curtis
- Kristin E. Killoran
- Laura E Kropp
Organizations
- National Heart, Lung, and Blood Institute
- Uniformed Services University of the Health Sciences