Chronic infection with a tissue‐invasive helminth attenuates sublethal anaphylaxis and reduces granularity and number of mast cells
Abstract
Immunoglobulin E (IgE)‐mediated anaphylaxis is a potentially fatal condition in which allergy effector cells rapidly discharge pre‐formed inflammatory mediators. Treatments that address the immune component of allergic anaphylaxis are inadequate. Helminths have been previously shown to suppress effector cell function; however, their ability to treat pre‐existing allergy remains unclear.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 15, 2020
- Source ID
- 10.1111/cea.13549
Entities
People
- Belinda Jackson‐thompson
- Dennis Mcdaniel
- Edward Mitre
- Laura E Kropp
- Louis Michael Thomas
Organizations
- National Institute of Allergy and Infectious Diseases
- Uniformed Services University of the Health Sciences