Higher levels of antibodies to the tumour-associated antigen cyclin B1 in cancer-free individuals than in patients with breast cancer
Abstract
Cyclin B1 is a checkpoint protein that regulates cell division from G2 to the M phase. Studies in mice have shown that cyclin B1 vaccine-induced immunity significantly delayed or prevented the spontaneous cancer development later in life. We hypothesized that if these results showing a protective effect of anti-cyclin B1 antibodies could be extrapolated to the human condition, cancer-free individuals should have higher levels of endogenous antibodies than patients with cancers characterized by the over-expression of this tumour-associated antigen. To test this hypothesis, we characterized a large (1739 subjects) number of multi-ethnic patients with breast cancer (which over-expresses cyclin B1) and matched controls for anti-cyclin B1 immunoglobulin (Ig)G antibodies. Multivariate analyses, after adjusting for the covariates, showed that cancer-free individuals had significantly higher levels of naturally occurring IgG antibodies to cyclin B1 than patients with breast cancer (mean ± standard deviation: 148·0 ± 73·6 versus 126·1 ± 67·8 arbitrary units per ml; P < 0·0001). These findings may have important implications for cyclin B1-based immunotherapy against breast cancer and many other cyclin B1-over-expressing malignancies.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 04, 2014
- Source ID
- 10.1111/cei.12385
Entities
People
- A M Namboodiri
- E Kistner-griffin
- G S Hamada
- J P Pandey
- M Iwasaki
- S Tsugane
- Y Kasuga
Organizations
- Avon Foundation for Women
- Department of Surgery
- Medical University of South Carolina
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health
- National Cancer Center
- United States Department of Defense