Early Life Status Epilepticus and Stress Have Distinct and Sex‐Specific Effects on Learning, Subsequent Seizure Outcomes, Including Anticonvulsant Response to Phenobarbital
Abstract
Neonatal status epilepticus (SE) is often associated with adverse cognitive and epilepsy outcomes. We investigate the effects of three episodes of kainic acid‐induced SE (3KA‐SE) and maternal separation in immature rats on subsequent learning, seizure susceptibility, and consequences, and the anticonvulsant effects of phenobarbital, according to sex, type, and age at early life (EL) event.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 14, 2014
- Source ID
- 10.1111/cns.12335
Entities
People
- Aristea S Galanopoulou
- Solomon L. Moshé
- Özlem Akman
Organizations
- Albert Einstein College of Medicine
- Citizens United for Research in Epilepsy
- Istanbul Bilim University
- National Institute of Neurological Disorders and Stroke
- United States Department of Defense
- University of California, Berkeley