Brain Region‐Specific Histopathological Effects of Varying Trajectories of Controlled Cortical Impact Injury Model of Traumatic Brain Injury
Abstract
Traumatic brain injury (TBI) occurs when the head is impacted by an external force causing either a closed or penetrating head injury through a direct or accelerating impact. In laboratory research, most of the TBI animal models focus on a specific region to cause brain injury, but traumatic injuries in patients do not always impact the same brain regions. The aim of this study was to examine the histopathological effects of different angles of mechanical injury by manipulating the trajectory of the controlled cortical impact injury (CCI) model in adult Sprague‐Dawley rats.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 18, 2016
- Source ID
- 10.1111/cns.12485
Entities
People
- Cesar V. Borlongan
- Mibel M. Pabón
- Naoki Tajiri
- Sandra Acosta
- Vivian A. Guedes
- Yuji Kaneko
Organizations
- National Institute of Neurological Disorders and Stroke
- National Institutes of Health
- United States Department of Defense
- University of South Florida