Association of rs2072446 in the NGFR gene with the risk of Alzheimer's disease and amyloid‐β deposition in the brain
Abstract
Alzheimer's disease (AD) is the most common form of dementia with a complex genetic background. The cause of sporadic AD (sAD) remains largely unknown. Increasing evidence shows that genetic variations play a crucial role in sAD. P75 neurotrophin receptor (p75NTR, encoded by NGFR) plays a critical role in the pathogenesis of AD. Yet, the relationship between NGFR gene polymorphisms and AD was less studied. This study aims to analyze the relationship of NGFR gene polymorphism with the risk of AD in the Chinese Han population and amyloid‐β deposition in the ADNI cohort.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 08, 2022
- Source ID
- 10.1111/cns.13965
Entities
People
- An‐yu Shi
- Cheng‐rong Tan
- Chen‐yang He
- Dong‐wan Chen
- Fan Zeng
- Gui‐hua Zeng
- Hui‐yun Li
- Jin‐tai Yu
- The Alzheimer’s Disease Neuroimaging Initiative*
- Yan-Jiang Wang
- Ying‐ying Shen
- Zuo‐teng Wang
Organizations
- Alzheimer's Disease Neuroimaging Initiative
- Army Medical University
- Canadian Institutes of Health Research
- Foundation for the National Institutes of Health
- Fudan University
- National Institute of Biomedical Imaging and Bioengineering
- National Institute on Aging
- National Institutes of Health
- National Natural Science Foundation of China
- Qingdao University
- United States Department of Defense