p53‐dependent up‐regulation of CDKN1A and down‐regulation of CCNE2 in response to beryllium
Abstract
Beryllium salts (here, beryllium sulphate) can produce a cytostatic effect in some cell types. The basis for this effect may include increased expression of proliferation inhibitors, reduced expression of proliferation promoters, or both. This study sought to determine the role of p53, the tumour‐suppressing transcription factor, in mediating beryllium‐induced cytostasis.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 09, 2016
- Source ID
- 10.1111/cpr.12291
Entities
People
- J. G. Cairncross
- P. Gorjala
- Ronald K. Gary
Organizations
- Army Research Office
- National Institutes of Health
- University of Calgary
- University of Nevada, Las Vegas