Assessment of different strategies for scalable production and proliferation of human myoblasts
Abstract
Myoblast transfer therapy (MTT) is a technique to replace muscle satellite cells with genetically repaired or healthy myoblasts, to treat muscular dystrophies. However, clinical trials with human myoblasts were ineffective, showing almost no benefit with MTT. One important obstacle is the rapid senescence of human myoblasts. The main purpose of our study was to compare the various methods for scalable generation of proliferative human myoblasts.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 19, 2019
- Source ID
- 10.1111/cpr.12602
Entities
People
- Bin Tean Teh
- Chun‐wei Li
- Ege Deniz Yildirim
- Jun‐hao Elwin Tan
- Kang Yu
- Min‐wen Jason Chua
- Ng Shyh-Chang
- Suet Lee Shirley Ding
- Suet‐mei Crystal Low
- Yan‐jiang Benjamin Chua
- Zongmin Jiang
Organizations
- Agency for Science, Technology and Research
- Chinese Academy of Sciences
- Duke–NUS Medical School
- Gates Foundation
- Institute of Zoology, Chinese Academy of Sciences
- Naval Medical Research Center
- Peking Union Medical College
- University of Chinese Academy of Sciences