The role of the substantia nigra pars reticulata in kindling resistance in rats with genetic absence epilepsy
Abstract
Genetic Absence Epilepsy Rats from Strasbourg (GAERS) show a resistance to secondary generalization of focal limbic seizures evoked by kindling. The substantia nigra pars reticulata (SNR) is involved in the propagation and modulation of seizures in kindling. We first examined the role of the SNRanterior and SNRposterior subregions in the resistance to the development of kindling in GAERS. Subsequently, to determine whether kindling resistance relates to differential sensitivity of γ‐aminobutyric acid γ‐aminobutyric acid (GABA)ergic or dopaminergic SNR neurons to kindling, we studied the effects of kindling‐inducing stimulations on parvalbumin (PRV; GABAergic neuron marker) or tyrosine hydroxylase (TH; dopaminergic neuron marker) immunoreactivity (ir), respectively, in GAERS and in nonepileptic control (NEC) Wistar rats that lack kindling resistance.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 16, 2015
- Source ID
- 10.1111/epi.13204
Entities
People
- Aristea S Galanopoulou
- Filiz Yilmaz Onat
- Medine I. Gulcebi
- Nihan Carcak
- Sema Ketenci Ozatman
- Solomon L. Moshé
- Tugba Eryigit
- Özlem Akman
Organizations
- Albert Einstein College of Medicine
- CURE Childhood Cancer
- Istanbul Bilim University
- Istanbul University
- Marmara University
- National Institute of Neurological Disorders and Stroke
- TÜBİTAK
- United States Department of Defense