Hypervascularization in mTOR‐dependent focal and global cortical malformations displays differential rapamycin sensitivity
Abstract
Patients with mammalian target of rapamycin (mTOR)–dependent malformations of cortical development (MCDs) associated with seizures display hyperperfusion and increased vessel density of the dysmorphic cortical tissue. Some studies have suggested that the vascular defect occurred independently of seizures. Here, we further examined whether hypervascularization occurs in animal models of global and focal MCD with and without seizures, and whether it is sensitive to the mTOR blocker, rapamycin, that is approved for epilepsy treatment in tuberous sclerosis complex.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 24, 2019
- Source ID
- 10.1111/epi.15969
Entities
People
- Angélique Bordey
- Longbo Zhang
- Shannon Teaw
- Tianxiang Huang
Organizations
- Central South University
- United States Department of Defense
- Yale University