Antiseizure and neuroprotective effects of delayed treatment with midazolam in a rodent model of organophosphate exposure
Abstract
Exposure to organophosphates (OPs) and OP nerve agents (NAs) causes status epilepticus (SE) and irreversible brain damage. Rapid control of seizure activity is important to minimize neuronal injury and the resulting neurological and behavioral disorders; however, early treatment will not be possible after mass release of OPs or NAs.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 24, 2019
- Source ID
- 10.1111/epi.16050
Entities
People
- Bonnie Roach
- Francis Edward Dudek
- Jay Spampanato
- Steven L. Bealer
- Wendy Pouliot
Organizations
- National Institute of Allergy and Infectious Diseases
- United States Army Medical Research Institute of Chemical Defense
- University of Utah