Disruption of intestinal barrier and endotoxemia after traumatic brain injury: Implications for post‐traumatic epilepsy
Abstract
Traumatic brain injury (TBI) may lead to the disruption of the intestinal barrier (IB), and to the escape of products of commensal gut bacteria, including lipopolysaccharide (LPS), into the bloodstream. We examined whether lateral fluid percussion injury (LFPI) and post‐traumatic epilepsy (PTE) are associated with the increased intestinal permeability and endotoxemia, and whether these events in turn are associated with PTE.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 23, 2021
- Source ID
- 10.1111/epi.16909
Entities
People
- Andréy Mazarati
- Don Shin
- Jesús‐servando Medel‐matus
- Jonathan P. Jacobs
- Raman Sankar
Organizations
- Congressionally Directed Medical Research Programs
- UCLA David Geffen School of Medicine
- University of California, Los Angeles
- VA Greater Los Angeles Healthcare System