Antiepileptogenic effects of rapamycin in a model of infantile spasms due to structural lesions
Abstract
Infantile spasms may evolve into persistent epilepsies including Lennox‐Gastaut syndrome. We compared adult epilepsy outcomes in models of infantile spasms due to structural etiology (multiple‐hit model) or focal cortical inflammation and determined the anti‐epileptogenic effects of pulse‐rapamycin, previously shown to stop spasms in multiple‐hit rats.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 02, 2021
- Source ID
- 10.1111/epi.16975
Entities
People
- Aristea S Galanopoulou
- Solomon L. Moshé
- Stephen W. Briggs
- Wenzhu B Mowrey
- Özlem Akman
Organizations
- Albert Einstein College of Medicine
- American Epilepsy Society
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- National Institute of Neurological Disorders and Stroke
- United States Department of Defense