Leveraging electrophysiologic correlates of word encoding to map seizure onset zone in focal epilepsy: Task‐dependent changes in epileptiform activity, spectral features, and functional connectivity
Abstract
Verbal memory dysfunction is common in focal, drug‐resistant epilepsy (DRE). Unfortunately, surgical removal of seizure‐generating brain tissue can be associated with further memory decline. Therefore, localization of both the circuits generating seizures and those underlying cognitive functions is critical in presurgical evaluations for patients who may be candidates for resective surgery. We used intracranial electroencephalographic (iEEG) recordings during a verbal memory task to investigate word encoding in focal epilepsy. We hypothesized that engagement in a memory task would exaggerate local iEEG feature differences between the seizure onset zone (SOZ) and neighboring tissue as compared to wakeful rest (“nontask”).
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 18, 2021
- Source ID
- 10.1111/epi.17067
Entities
People
- Gregory Worrell
- Irena Balzekas
- Krishnakant Saboo
- Michal T. Kucewicz
- Ravishankar K. Iyer
- Vaclav Kremen
- Yogatheesan Varatharajah
Organizations
- Czech Technical University in Prague
- Defense Advanced Research Projects Agency
- Gdańsk University of Technology
- Mayo Clinic
- National Institute of General Medical Sciences
- National Institutes of Health
- University of Illinois Urbana–Champaign