Incidence and risk factors of posttraumatic epilepsy following pediatric traumatic brain injury: A systematic review and meta‐analysis
Abstract
Posttraumatic epilepsy (PTE) is a well‐known chronic complication following traumatic brain injury (TBI). Despite some evidence that age at the time of injury may influence the likelihood of PTE, the incidence of PTE in pediatric populations remains unclear. We therefore conducted a systematic review to determine the overall reported incidence of PTE, and explore potential risk factors associated with PTE after pediatric TBI. A comprehensive literature search of the PubMed, Embase, and Web of Science databases was conducted, including randomized controlled trials and cohort studies assessing the incidence of PTE in TBI pediatric patients. We excluded studies with a sample size of p = .040), severe TBI (CIR = 1.81, 95% CI = 1.23–2.67, p p = .024) increased the risk of PTE in this population. Other factors, including male sex and neurosurgical intervention, were nonsignificantly associated with a higher incidence of PTE. In conclusion, PTE is a significant chronic complication following childhood TBI, similar to in the adult population. Further standardized investigation into clinical risk factors and management guidelines is warranted. PROSPERO ID# CRD42021245802.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 04, 2022
- Source ID
- 10.1111/epi.17398
Entities
People
- Ana Antonic‐baker
- Bridgette D Semple
- Frederick P. Mariajoseph
- Praba Sekhar
- Sarah S. Rewell
- Terence J. O’brien
- Zhibin Chen
Organizations
- Alfred Health
- Monash University
- National Health and Medical Research Council
- United States Department of Defense
- University of Melbourne