Hypothesis: Wound‐induced TLR3 activation stimulates endogenous retinoic acid synthesis and signalling during regeneration
Abstract
Although the mechanism is unclear, it has been shown that genetically normal adult mice with a large wound form de novo morphogenesis of hair follicles in wound‐induced hair neogenesis (WIHN)(1). We focused on how tissues recognize damage signals and identified that double‐stranded RNA (dsRNA)‐mediated toll‐like receptor 3 (TLR3) activation stimulates WIHN. Here, we propose a hypothesis that TLR3 stimulates retinoic acid synthesis and signalling to allow for regeneration, suggesting that common clinical methods of facial rejuvenation in human subjects through damage (such as lasers or dermabrasion), and the use of topical retinoids reflect the same biologic pathway.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2019
- Source ID
- 10.1111/exd.13931
Entities
People
- Dongwon Kim
- Luis A Garza
Organizations
- Johns Hopkins School of Medicine
- Maryland Stem Cell Research Fund
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- United States Department of Defense