Histatin‐1 is an endogenous ligand of the sigma‐2 receptor
Abstract
The Sigma‐2 receptor (S2R) (a.k.a TMEM97) is an important endoplasmic reticular protein involved in cancer, cholesterol processing, cell migration, and neurodegenerative diseases, including Niemann–Pick Type C. While several S2R pharmacologic agents have been discovered, its recent (2017) cloning has limited biological investigation, and no endogenous ligands of the S2R are known. Histatins are a family of endogenous antimicrobial peptides that have numerous important effects in multiple biological systems, including antifungal, antibacterial, cancer pathogenesis, immunomodulation, and wound healing. Histatin‐1 (Hst1) has important roles in epithelial wound healing and cell migration, and is the primary wound healing agent in saliva. Little is understood about the downstream machinery that underpins the effects of histatins, and no mammalian receptor is known to date. In this study, we show, using biophysical methods and functional assays, that Hst1 is an endogenous ligand for S2R and that S2R is a mammalian receptor for Hst1.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 23, 2021
- Source ID
- 10.1111/febs.16108
Entities
People
- Arun Balasubramaniam
- Deepak Shukla
- Dhara Shah
- Hyun Lee
- Hyunjoon Kong
- Kyung‐no Son
- Marwan Ali
- Ryan Cree Miller
- Stephanie M. Cologna
- Sushma Kalmodia
- Vinay K. Aakalu
Organizations
- Congressionally Directed Medical Research Programs
- National Eye Institute
- National Institute of Neurological Disorders and Stroke
- Research to Prevent Blindness
- University of Illinois Urbana–Champaign
- University of Illinois at Chicago
- Veterans Health Administration Office of Research and Development