Upstream lipid and metabolic systems are potential causes of Alzheimer's disease, Parkinson's disease and dementias
Abstract
Brain health requires circuits, cells and molecular pathways to adapt when challenged and to promptly reset once the challenge has resolved. Neurodegeneration occurs when adaptability becomes confined, causing challenges to overwhelm neural circuitry. Studies of rare and common neurodegenerative diseases suggest that the accumulation of lipids can compromise circuit adaptability. Using microglia as an example, we review data that suggest increased lipid concentrations cause dysfunctional inflammatory responses to immune challenges, leading to Alzheimer's disease, Parkinson's disease and dementia. We highlight current approaches to treat lipid metabolic and clearance pathways and identify knowledge gaps towards restoring adaptive homeostasis in individuals who are at‐risk of losing cognition.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 12, 2022
- Source ID
- 10.1111/febs.16638
Entities
People
- Ole Isacson
- Oliver Cooper
- Penelope J. Hallett
Organizations
- Borchard Foundation Center on Law and Aging
- Harvard Medical School
- National Institutes of Health
- United States Department of Defense