Analysis of fitness costs associated with metronidazole and amoxicillin resistance in Helicobacter pylori
Abstract
Increasing rates of antibiotic resistance are a major concern for all pathogens, including H. pylori. However, increased resistance often coincides with a decrease in relative fitness of the pathogen in the absence of the antibiotic, raising the possibility that increased resistance can be mitigated for some antibiotics by improved antibiotic husbandry. Therefore, a greater understanding of which types of antibiotic resistance create fitness defects in H. pylori may aid rational treatment strategies.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 16, 2020
- Source ID
- 10.1111/hel.12724
Entities
People
- D Scott Merrell
- Ian H. Windham
Organizations
- National Institutes of Health
- Uniformed Services University of the Health Sciences
- United States Department of Defense