Differential methylation of the promoter and first exon of the RASSF1A gene in hepatocarcinogenesis
Abstract
Aberrant methylation of the promoter, P2, and the first exon, E1, regions of the tumor suppressor gene RASSF1A, have been associated with hepatocellular carcinoma (HCC), albeit with poor specificity. This study analyzed the methylation profiles of P1, P2 and E1 regions of the gene to identify the region of which methylation most specifically corresponds to HCC and to evaluate the potential of this methylated region as a biomarker in urine for HCC screening.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 09, 2014
- Source ID
- 10.1111/hepr.12449
Entities
People
- Batbold Boldbaatar
- Chi‐tan Hu
- James P. Hamilton
- Lijia Xie
- Selena Y. Lin
- Shun‐hua Chen
- Stephen J. Meltzer
- Surbhi Jain
- Timothy M. Block
- Wei Song
- Ying‐hsiu Su
Organizations
- Drexel University
- Johns Hopkins University
- National Cheng Kung University
- National Institutes of Health
- Prevent Cancer Foundation
- Sidney Kimmel Comprehensive Cancer Center
- Tzu Chi University
- United States Department of Defense