A phenotypical map of disseminated hepatocellular carcinoma suggests clonal constraints in metastatic sites
Abstract
Access to tissue in patients with hepatocellular carcinoma (HCC) is limited compared to other malignancies, particularly at advanced stages. This has precluded a thorough characterisation of molecular drivers of HCC dissemination, particularly in relation to distant metastases. Biomarker assessment is restricted to early stages, and paired primary–metastatic comparisons between samples from the same patient are difficult.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 21, 2019
- Source ID
- 10.1111/his.13809
Entities
People
- Alda Wakamatsu
- Aline K Assato
- Amanda J. Craig
- Augusto Villanueva
- Carlos Villacorta-Martín
- Delia D'Avola
- Flair J. Carrilho
- Ismail Labgaa
- Miho Maeda
- Sebastiao N Martins-Filho
- Swan N. Thung
- Venancio A F Alves
Organizations
- Coordenação de Aperfeicoamento de Pessoal de Nível Superior
- Icahn School of Medicine at Mount Sinai
- Lausanne University Hospital
- Terry Fox foundation
- United States Department of Defense
- University Health Network
- University of Navarre
- University of São Paulo