NOD1 and NOD2 in inflammatory and infectious diseases

Abstract

It has been long recognized that NOD1 and NOD2 are critical players in the host immune response, primarily by their sensing bacterial peptidoglycan‐conserved motifs. Significant advances have been made from efforts that characterize their upstream activators, assembly of signaling complexes, and activation of downstream signaling pathways. Disruption in NOD1 and NOD2 signaling has also been associated with impaired host defense and resistance to the development of inflammatory diseases. In this review, we will describe how NOD1 and NOD2 sense microbes and cellular stress to regulate host responses that can affect disease pathogenesis and outcomes.

Document Details

Document Type
Pub Defense Publication
Publication Date
Jul 17, 2020
Source ID
10.1111/imr.12902

Entities

People

  • Bruno C Trindade
  • Grace Chen

Organizations

  • National Institute of Food and Agriculture
  • National Institutes of Health
  • United States Department of Defense
  • University of Michigan

Tags

Fields of Study

  • Biology
  • Medicine

Readers

  • Infectious Disease/Epidemiology
  • Molecular Biology and Genetics
  • Molecular and genetic basis of cancer.