Applications of CRISPR technology in cellular immunotherapy
Abstract
CRISPR technology has transformed multiple fields, including cancer and immunology. CRISPR‐based gene editing and screening empowers direct genomic manipulation of immune cells, opening doors to unbiased functional genetic screens. These screens aid in the discovery of novel factors that regulate and reprogram immune responses, offering novel drug targets. The engineering of immune cells using CRISPR has sparked a transformation in the cellular immunotherapy field, resulting in a multitude of ongoing clinical trials. In this review, we discuss the development and applications of CRISPR and related gene editing technologies in immune cells, focusing on functional genomics screening, gene editing‐based cell therapies, as well as future directions in this rapidly advancing field.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 14, 2023
- Source ID
- 10.1111/imr.13241
Entities
People
- Liqun Zhou
- Paul A. Renauer
- Shao‐yu Fang
- Sidi Chen
- Xiaoyu Zhou
Organizations
- Alliance for Cancer Gene Therapy
- Cancer Research Institute
- National Institutes of Health
- United States Department of Defense
- Yale University