Targeting ferroptosis in gastric cancer: Strategies and opportunities
Abstract
Ferroptosis is a novel form of programmed cell death morphologically, genetically, and biochemically distinct from other cell death pathways and characterized by the accumulation of iron‐dependent lipid peroxides and oxidative damage. It is now understood that ferroptosis plays an essential role in various biological processes, especially in the metabolism of iron, lipids, and amino acids. Gastric cancer (GC) is a prevalent malignant tumor worldwide with low early diagnosis rates and high metastasis rates, accounting for its relatively poor prognosis. Although chemotherapy is commonly used to treat GC, drug resistance often leads to poor therapeutic outcomes. In the last several years, extensive research on ferroptosis has highlighted its significant potential in GC therapy, providing a promising strategy to address drug resistance associated with standard cancer therapies. In this review, we offer an extensive summary of the key regulatory factors related to the mechanisms underlying ferroptosis. Various inducers and inhibitors specifically targeting ferroptosis are uncovered. Additionally, we explore the prospective applications and outcomes of these agents in the field of GC therapy, emphasizing their capacity to improve the outcomes of this patient population.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 30, 2023
- Source ID
- 10.1111/imr.13280
Entities
People
- Amit K. Tiwari
- Che Zhang
- Guangzhao Pan
- Jiahan Le
- Jiang‐jiang Qin
- Yitao Chen
Organizations
- Congressionally Directed Medical Research Programs
- University of Arkansas for Medical Sciences
- University of Chinese Academy of Sciences
- Zhejiang Chinese Medical University
- Zhejiang Provincial Natural Science Foundation