A PEGylated fibrin hydrogel‐based antimicrobial wound dressing controls infection without impeding wound healing
Abstract
Combat injuries are associated with a high incidence of infection, and there is a continuing need for improved approaches to control infection and promote wound healing. Due to the possible local and systemic adverse effects of standard 1% cream formulation (Silvadene), we had previously developed a polyethylene glycol (PEGylated) fibrin hydrogel (FPEG)‐based wound dressing for the controlled delivery of silver sulfadiazine (SSD) entrapped in chitosan microspheres (CSM). In this study, we have evaluated the antimicrobial and wound healing efficacy of SSD‐CSM‐FPEG using a full‐thickness porcine wound infected with Pseudomonas aeruginosa. Infected wounds treated with a one‐time application of the SSD‐CSM‐FPEG wound dressing demonstrated significantly reduced bacterial bioburden over time (99·99% of reduction by day 11; P SSD‐CSM‐FPEG wound dressing effectively controls P. aeruginosa infection and promotes wound healing by providing a favourable environment that induces neovascularisation. Collectively, sustained release of SSD using fibrin hydrogel exhibited enhanced benefits when compared with the currently available SSD treatment, and this may have significant implications in the bacterial reduction of infected wounds in military and civilian populations.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 02, 2017
- Source ID
- 10.1111/iwj.12791
Entities
People
- Andrew Harding
- Jie Li
- Joel Gil
- Jose Valdes
- Michael Solis
- Robert J Christy
- Shanmugasundaram Natesan
- Stephen C. Davis
Organizations
- United States Army Medical Research and Development Command
- University of Miami