Effect of Virus Dose and Nonoxynol‐9 on the Genital Transmission of SIV in Rhesus Macaques
Abstract
One inoculation of cell‐free SIVMAC‐ (50 TC1D50) caused persistent viremia in nine of 13 female rhesus macaques inoculated intravaginally. Persistent viremia was produced in two of four male rhesus macaques by twice placing cell‐free SIVMAC (50 TCID50) onto the skin and urethral os of the penis. Placing a spermicide containing nonoxynol‐9 into the vaginal canal prior to repeated intravaginal inoculations of SIV prevented transmission of the virus in three of six female rhesus macaques.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 01, 1990
- Source ID
- 10.1111/j.1600-0684.1990.tb00445.x
Entities
People
- Andrew G. Hendrickx
- Christopher J. Miller
- Myra Jennings
- Nancy J. Alexander
- Preston A. Marx
- Steven M. Joye
- Suganto Sutjipto
Organizations
- Eastern Virginia Medical School
- United States Army Medical Command
- United States Public Health Service
- University of California, Davis