Serial pathogenesis study of SIV brain infection
Abstract
A serial study of early SIV brain infection revealed initial involvement of leptomeninges, followed by perivascular infection of brain parenchyma. Severity of SIV encephalitis correlated with severity of systemic disease rather than with length of infection. Diffuse white matter disease was not observed, and there was little evidence of SIV infection of brain endothelial cells. SIV infection of leptomeninges is separate from infection of the brain, which appears to be due to transvascular spread of infected monocytes/macrophages.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 01, 1991
- Source ID
- 10.1111/j.1600-0684.1991.tb00521.x
Entities
People
- Dorothy J. Kuebler
- Fu‐sen Hu
- Gary B. Baskin
- Jennifer E. Michaels
- Leroy R. Sharer
- Louis N. Martin
- Michael Murphey‐corb
Organizations
- National Institutes of Health
- New Jersey Medical School
- United States Army Medical Command
- United States Public Health Service