Unravelling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Gender‐specific changes in the microRNA expression profiling in ME/CFS
Abstract
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystem illness characterized by medically unexplained debilitating fatigue with suggested altered immunological state. Our study aimed to explore peripheral blood mononuclear cells (PBMCs) for microRNAs (miRNAs) expression in ME/CFS subjects under an exercise challenge. The findings highlight the immune response and inflammation links to differential miRNA expression in ME/CFS. The present study is particularly important in being the first to uncover the differences that exist in miRNA expression patterns in males and females with ME/CFS in response to exercise. This provides new evidence for the understanding of differential miRNA expression patterns and post‐exertional malaise in ME/CFS. We also report miRNA expression pattern differences associating with the nutritional status in individuals with ME/CFS, highlighting the effect of subjects' metabolic state on molecular changes to be considered in clinical research within the NINDS/CDC ME/CFS Common Data Elements. The identification of gender‐based miRNAs importantly provides new insights into gender‐specific ME/CFS susceptibility and demands exploration of sex‐suited ME/CFS therapeutics.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 14, 2020
- Source ID
- 10.1111/jcmm.15260
Entities
People
- Amanpreet K. Cheema
- Elisa Oltra
- Eloy Almenar‐pérez
- Eva Martín‐martínez
- Fanny Collado
- Jesus Castro-Marrero
- Jose Alegre
- Leonor Sarria
- Lubov Nathanson
- Mary A. Fletcher
- Mina Bekheit
- Nancy G. Klimas
Organizations
- Congressionally Directed Medical Research Programs
- National Health Service
- National Institute of Allergy and Infectious Diseases
- National Institute of Neurological Disorders and Stroke
- Nova Southeastern University
- South Florida Veterans Affairs Foundation for Research and Education
- United States Department of Veterans Affairs
- Vall d'Hebron Hospital Universitari