The role of neurotensin in vulnerability for self‐injurious behaviour: studies in a rodent model
Abstract
Self‐injurious behaviour is a debilitating characteristic that is commonly expressed in people with autism and other neurodevelopmental disorders, but the neurobiological basis of this maladaptive behaviour is not understood. Abnormal dopaminergic and glutamatergic neurotransmission has been implicated, especially in relation to basal ganglia and mesocorticolimbic circuits. As neurotensin is an important modulator of dopamine and glutamate in these circuits, we investigated its potential role in vulnerability for self‐injury, using the pemoline model in rats.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 23, 2018
- Source ID
- 10.1111/jir.12519
Entities
People
- A. M. Muehlmann
- Darragh P Devine
- S. L. Wolfman
Organizations
- National Institute of Mental Health
- United States Department of Defense
- University of Florida