Factors promoting vulnerability to dysregulated stress reactivity and stress‐related disease
Abstract
Effective coordination of the biological stress response is integral for the behavioural well‐being of an organism. Stress reactivity is coordinated by an interplay of the neuroendocrine system and the sympathetic nervous system. The hypothalamic‐pituitary‐adrenal (HPA) axis plays a key role in orchestrating the bodily responses to stress, and the activity of the axis can be modified by a wide range of experiential events. This review focuses on several factors that influence subsequent HPA axis reactivity. Some of these factors include early‐life adversity, exposure to chronic stress, immune activation and traumatic brain injury. The central premise is that each of these experiences serves as a general vulnerability factor that accelerates future HPA axis reactivity in ways that make individuals more sensitive to stress challenges, therefore feeding forward into the exacerbation of ongoing (or greater susceptibility toward) future stress‐related disease states, especially as they pertain to negative affect and overall brain health.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 01, 2018
- Source ID
- 10.1111/jne.12641
Entities
People
- Aldo B. Lucion
- Ashley L Russell
- Carolina D Munhoz
- Jeffrey G Tasker
- Jenny Fiedler
- Tao‐yiao John Wu
- Terrence Deak
Organizations
- Binghamton University
- Center for Neuroscience and Regenerative Medicine
- Federal University of Rio Grande do Sul
- National Council for Scientific and Technological Development
- National Institutes of Health
- Office of Naval Research
- São Paulo Research Foundation
- Tulane University of Louisiana
- Uniformed Services University of the Health Sciences
- University of Chile
- University of São Paulo