Variations in maternal adenylate cyclase genes are associated with congenital Zika syndrome in a cohort from Northeast, Brazil
Abstract
Vertical transmission of Zika virus (ZIKV) is associated with congenital malformations but the mechanism of pathogenesis remains unclear. Although host genetics appear to play a role, no genetic association study has yet been performed to evaluate this question. In order to investigate if maternal genetic variation is associated with Congenital Zika Syndrome (CZS), we conducted a case–control study in a cohort of Brazilian women infected with ZIKV during pregnancy.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 17, 2018
- Source ID
- 10.1111/joim.12829
Entities
People
- A. Melo
- A. Tanuri
- B. L. F. Schamber‐reis
- C. A. Stratakis
- Cynthia Cardoso
- F. R. Faucz
- G. S. De Azevedo
- J. J. Mattapallil
- J. S. Tavares
- P. Pezzuto
- R. S. Aguiar
- Á. D. Rossi
Organizations
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Federal University of Rio de Janeiro
- National Council for Scientific and Technological Development
- Uniformed Services University of the Health Sciences