Cluster Confidence Index: A Streamline‐Wise Pathway Reproducibility Metric for Diffusion‐Weighted MRI Tractography
Abstract
Diffusion‐weighted magnetic resonance imaging tractography can be used to create models of white matter fascicles. Anatomical and pathological variability between subjects can drastically alter the tractography output, so standardizing results across a cohort is nontrivial. Furthermore, tractography methods have inherently low reproducibility due to stochasticity (for probabilistic methods) and subjective decisions, since the final fascicle model often requires a manual intervention step performed by an expert human operator to control both outliers and systematic false‐positive pathways, as defined by prior knowledge of anatomy.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 21, 2017
- Source ID
- 10.1111/jon.12467
Entities
People
- Anisha Keshavan
- Bagrat Amirbekian
- Kesshi M Jordan
- Roland G. Henry
Organizations
- National Institutes of Health
- United States Department of Defense
- University of California, San Francisco