Tissue‐engineered 3D microvessel and capillary network models for the study of vascular phenomena
Abstract
Advances in tissue engineering, cell biology, microfabrication, and microfluidics have led to the development of a wide range of vascular models. Here, we review platforms based on templated microvessel fabrication to generate increasingly complex vascular models of (i) the tumor microenvironment, (ii) occluded microvessels, and (iii) perfused capillary networks. We outline fabrication guidelines and demonstrate a number of experimental methods for probing vascular function such as permeability measurements, tumor cell intravasation, flow characterization, and endothelial cell morphology and proliferation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 01, 2017
- Source ID
- 10.1111/micc.12360
Entities
People
- Andrew D. Wong
- Jackson Destefano
- Max I Bogorad
- Peter C. Searson
Organizations
- American Heart Association
- Defense Threat Reduction Agency
- Johns Hopkins University