Global microRNA profiling identified miR‐10b‐5p as a regulator of neurofibromatosis 1 (NF1)‐glioma migration
Abstract
Neurofibromatosis 1 (NF1) is an autosomal‐dominant cancer predisposition syndrome caused by loss of function alterations involving the NF1 locus on chromosome 17. The most common brain tumours encountered in affected patients are low‐grade gliomas (pilocytic astrocytomas), although high‐grade gliomas are also observed at increased frequency. While bi‐allelic NF1 loss characterizes these tumours, previous studies have suggested noncoding RNA molecules (microRNA, miR) may have important roles in dictating glioma biology.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 22, 2020
- Source ID
- 10.1111/nan.12641
Entities
People
- D. H. Gutmann
- E. L. Imada
- Fausto J Rodriguez
- H. Ames
- J. S. Nix
- L. Marchionni
- M. Yuan
Organizations
- Foundation for the National Institutes of Health
- Johns Hopkins University
- United States Department of Defense
- Washington University in St. Louis