Reactive oxygen species overproduction and MAP kinase phosphatase‐1 degradation are associated with gastroparesis in a streptozotocin‐induced male diabetic rat model
Abstract
Diabetic gastroparesis in human and animal models suggest different developmental causes in females vs males. Previously, we demonstrated that although male and female diabetic gastroparetic rats exhibited similarity in disease pathology, molecular mechanisms were different: slow gastric emptying in male diabetic gastroparetic rats was not associated with the level of expression and dimerization of neuronal nitric oxide synthase α in gastric tissues, as was demonstrated in females. Male gastroparesis may involve other mechanisms, such as oxidative stress. We hypothesize that sustained increased reactive oxygen species (ROS) and degradation of MAP kinase phosphatase‐1 with subsequent unregulated activation of c‐Jun N‐terminal kinase and p38MAP kinase pathways are associated with gastroparesis in a male diabetic rat model.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 02, 2017
- Source ID
- 10.1111/nmo.13218
Entities
People
- M Showkat Ali
- P. Naik
- R. Mccallum
- R. Smiley
Organizations
- Texas Tech University
- William Beaumont Army Medical Center